Day 1 Review: Nodal Flow

The study of nodal flow and Hensen's node reveals fundamental mechanisms at the origin of the internal asymmetry of organisms. Within Hensen's node, cilia perform a rotational movement that transports small molecules inwards, thus creating an environment conducive to the concentration of vesicles. These vesicles, by colliding, release morphogens that play a crucial role in the activation and inhibition of genes, leading to the formation of asymmetric organs such as the heart and the liver. This genetic process is the basis of functional asymmetry, essential for the development of brain connections and long-term movements.

Nodal flow constitutes the starting point of this asymmetry, orchestrating the movement of nodal fluid and the concentration of vesicles. Originating from the epiblast, these vesicles trigger genetic cascades involving key genes such as Sonic Hedgehog and FGFs (Fibroblast Growth Factors). This early organizational mechanism is fundamental for the formation of the mesoderm, which divides into intra-embryonic and extra-embryonic mesoderm. In osteopathy, understanding these processes is crucial, as it influences our mental image and our therapeutic approach, highlighting the importance of bodily perception in the healing process.