11- Revision_ Origin of Body Asymmetry

Body asymmetry originates from the movement of the notochordal process, which generates Hensen's node, a key element in the formation of the notochordal axis. This node houses microcilia which, according to research related to Kartagener's syndrome, are involved in laterality disorders. These microcilia, present in structures such as spermatozoa, the uterus, fallopian tubes, and bronchi, perform a rotational movement that concentrates molecules towards the left side of the embryo. This molecular concentration process leads to the release of vesicles containing pre-morphogenetic molecules, thus contributing to an internal asymmetry that favors the development of organs like the heart on the left.

Although the external appearance of the body may seem symmetrical, significant asymmetry exists internally, affecting areas such as the brain, eyes, and extending between the sacrum and the base of the skull. This organization of embryonic laterality is reinforced by the release of specific proteins, called sonotic HETCH, and genes containing zinc. These elements play a crucial role in activating the corrupted and hypercalcium systems, promoting uneven cellular development that accentuates asymmetry within the organism.